宋雷,男,汉族,1975年3月生,中共党员,博士,副教授,硕士生导师
一、主要学习经历
1993.9-1997.6,兰州医学院,药学专业,医学学士;
2003.9 – 2009.6,兰州大学,生态学专业,理学博士;
二、主要工作简历
1997.9-2003.8 甘肃省第二人民医院药剂科,药师
2009.9-2012.5 中国科学院近代物理研究所辐射生物效应研究室博士后工作站,博士后
2012.6-至今皇冠最新官网crown官网-(中国)官方网站医学部,副教授
三、教学科研工作及成果
(一)教学工作:
2012年6月-至今为皇冠最新官网crown官网-(中国)官方网站医学院机能学教研室专任教师,教授课程药理学、医用化学、民族药学概论和临床药理学。
(二)科研工作:
在研项目:
中央高校基本科研费项目重点项目“8-氨基异紫堇碱诱导胃癌细胞凋亡和周期阻滞的分子机制研究”(31920190095),2019/04-2021/04,在研
主持完成项目:
国家自然科学基金青年基金项目“肾透明细胞癌干细胞表面标志物的鉴定”(81000961),2011/01-2011/12,已结题;
中央高校基本科研费项目重点项目“异紫堇碱衍生物靶向肿瘤干细胞的研究”(31920130036),2013/04-2015/04,已结题;
中央高校基本科研费项目重大培育项目“无血清悬浮法构建不同L-H状态胃癌干细胞的研究”(31920160009),2016/04-2018/04,已结题。
参与完成项目:
国家民委项目“醋酸棉酚诱导肿瘤细胞DNA双链断裂机制研究”(12XBZ011),2012/8-2014/8.
发表论文著作:
Lei Song, Wenling Ye,Yong Cui, Jianzhong Lu, Yanna Zhang, Nan Ding, WentaoHu, Hailong Pei, Zhongjin Yue, Guangming Zhou, 2017. Ecoto-5’-nucleotidase(CD73) is a biomarker for clear cell renal carcinoma stem-like cells.Oncotarget 8(19):31977-31992.
Lei Song, Feng-Min Li*, Xian-Wei Fan, You-Cai Xiong, Wen-Qi Wang, Xu-Ben Wu,Neil C. Turner., 2009. Soil water availability and plant competition affect theyield of spring wheat. European Journal of Agronomy 31, 51-60.
Lei Song, Da-Wei Zhang, Feng-Min Li*, Xian-Wei Fan, Qiang Ma, Neil C.Turner., 2010. Soil water availability alters the inter- and intra-cultivar competitionof three spring wheat cultivars bred in different eras. Journal of Agronomy andCrop Science 196, 323-335.
Guan XK#,Song L# (共同一作), WangTC, Turner NC, Li FM*, 2015. Effect of drought on the gas exchange, chlorophyllfluorescence and yield of six different-era spring wheat cultures. Journal ofAgronomy and Crop Science 201:253-266.
Wei Wang,Wento Hu, Ya Wang, Yong An, Lei Song,Panfeng Shang, Zhongjin Yue, 2020. Long non-coding RNA UCA1 promotes malignantphenotypes of renal cancer cells by modulating the miR-182-5p/DLL4 axis as aceRNA. Molecular Cancer 19:18.
Zhao F, ZhaoJ, Song L, Zhang YQ, Guo Z, Yang KH,2017. The induction of apoptosis and autophagy in human hepatoma SMMC-7721cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa. Apoptosis22:1461-1472.
Zhang YQ,Zhao F*, Song L, Gan HY, Xie XF,2017. Systematic Review and Meta-analysis of Endostar Combined WithTranscatheter Arterial Chemoembolization (TACE) Versus TACE Alone forHepatocellular Carcinoma. Journal of Evidence-Based Complementary andAlternative Medicine. DOI:10.1177/2156587217730461
Fei Zhao,Yongfeng Wang, Lei Song, Jiaxin Jin,Yaqing Zhang, Hongyun Gan, Kehu Yang, 2017. Synergistic apoptotic effect ofD-Fraction from Grifola frondosa and Vitamin C on hepatocellular carcinomaSMMC-7721 cells. Integrative Cancer Therapies 16:205-214.
Jin Zhao*,Zhong Guo, Shuyan Pei, Lei Song,Chenjing Wang, Jianxiu Ma, Long Jin, Yanqing Ma, Renke He, Jianbin Zhong, YingMa and Hong Zhang, 2017. pATM and γH2AX are effective radiation biomarkers inassessing the radiosensitivity of 12C6+ in human tumorcells. Cancer Cell International 17:49-59.
Guan XK,Turner NC, Song L, Gu YJ, Wang TC,Li FM*, 2016.Soil carbon sequestration by three perennial legume pastures is greater indeeper soil layers than in the surface soil. Biogeosciences 13:527-534.
Yi Yu, WeiWang, Lei Song, Wentao Hu, Chi Dong,Hailong Pei, Guangming Zhou, Zhongjin Yue, 2015. Ecoto-5’-nucleotidaseexpression is associated with the progression of renal cell carcinoma. OncologyLetters 9:2485-2494.
Guo Z, ZhaoJ, Song L, Ma JX, Wang CJ, Pei SY,Jiang C, Li SB, 2014. Induction of H2AX phosphorylation in tumor cells bygossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family.Cancer Cell International 14:141-149.
Zhao J, GuoZ, Zhang H, Wang ZH, Song L, Ma JX,Pei SY, Wang CJ, 2013. The potential value of the neutral comet assay and rH2AXfoci assay in assessing the radiosensitivity of carbon beam in human tumor celllines. Radiol Oncol 47(3):247-257.
Lei Chang,Wentao Hu, Caiyong Ye, Bin Yao, Lei Song,Xin Wu, Nan Ding, Jufang Wang*, Guangming Zhou*, 2012. miR-3928 actives ATRpathway by target Dicer. RNA Biology 9, 10:1247-1254.
Xian-Wei Fan,Feng-Min Li*, Lei Song, You-CaiXiong, Li-Zhe An, Yu Jia, Xiang-Wen Fang., 2009. Defense strategy of old andmodern spring wheat varieties during soil drying. Physiologia Plantarum 136, 310-323.
宋雷,刘勇,马伟林,陈林林,郭忠*.氟达拉滨联合不同辐射作用于肾癌细胞株786-O的效果观察[J].中华放射肿瘤学杂志,2016,25(6):646-651.(CSCD核心)
宋 雷,叶文凌*,刘勇,王伟,黄睿.一种改进的肾透明细胞癌原代细胞培养方法[J].第三军医大学学报,2016,38(8):714-717. (CSCD核心)
宋雷*,绽春蕊,杨世英,马伟林,马贤,柳军玺. 杭黄菊提取物的体外抗菌活性研究[J].天然产物研究与开发,2015,27(3):455-458. (CSCD核心)
宋雷,郭忠,杨世英,赵晋.肾癌干细胞与表观遗传学调控研究进展[J].中国肿瘤临床,2013,40(23):1477-1480.(CSCD核心)
杨世英,柳军玺,张鑫,宋雷*.异紫堇碱衍生物抗菌及抑肿瘤作用的研究[J].食品与生物技术学报,2015,34(1):79-83. (CSCD核心)
宋雷,一种肿瘤细胞原代培养的方法. 中国发明专利:ZL 2014 1 0117528.7[P],2016-6-1.
周光明,王菊芳,宋雷,叶文凌,裴海龙,张亚楠,丁楠,孙放,叶才勇,高笑菲,徐瑚珊.CD73作为肾透明细胞癌干细胞表面标志物的应用. 中国发明专利:ZL 2013 1 0181801.8[P], 2015-1-7.
获奖情况:
甘肃省高等学校科学研究优秀成果奖(科学技术):磷酸化组蛋白rH2AX在肿瘤诊断与治疗中的应用研究 自然科学类一等奖(2015KJ-029),5/6
甘肃省药学发展奖:基于西北特色植物秃疮花主要成分异紫堇碱的抗癌药物开发二等奖(2015-Y2-04-R5)
四、社会兼职和社会服务
中国细胞生物学学会会员
甘肃省执业药师协会会员
中国流式细胞学会会员